HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441450Generated: November 2, 2026
3-(3-Chlorophenyl)-alpha-(4-fluorophenyl)-2,1-benzisoxazole-5-methanol → [3-(3-Chlorophenyl)-2,1-benzisoxazol-5-yl](4-fluorophenyl)-methanone
https://huagongshe.com/reaction/1441450
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(3-Chlorophenyl)-alpha-(4-fluorophenyl)-2,1-benzisoxazole-5-methanol | HCID 17976105 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(3-Chlorophenyl)-2,1-benzisoxazol-5-yl](4-fluorophenyl)-methanone | HCID 17976104 | — |
Reaction Steps
A mixture of intermediate 1 (0.0514 mol) and MnO2 (18 g) in 1,4-dioxane (200 ml) was stirred at 80° C. for 3 hours, then cooled to room temperature and filtered over celite. The solvent was evaporated till dryness. The product was used without further purification, yielding (quant.) of [3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl](4-fluorophenyl)-methanone (intermediate 2), mp. 165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07655654B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-bdc8b4cc539c49e5b63981ab525ffd94 |
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| Source note | uspto-grants-2010_02 |
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