HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441470Generated: November 1, 2026
Ammonium Acetate → 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)-quinazolinone
https://huagongshe.com/reaction/1441470
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2,2,2-trichloro-N-[2-(3-chlorobenzoyl)-4-(4-methylbenzoyl)phenyl]-acetamide | HCID 68689044 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)-quinazolinone | HCID 68687432 | 63.4% |
Reaction Steps
A mixture of intermediate 21 (0.0085 mol) and acetic acid, ammonium salt (0.0169 mol) in DMSO (42 ml) was stirred at 60° C. for 4 hours then cooled and poured out into ice water. The precipitate was filtered, washed with water, taken up in warm CH3CN, filtered off and dried under a vacuo, yielding 2.02 g (63%) of 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)-quinazolinone (intermediate 22), mp.>260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07655654B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-620bb00027ed4f649c4f0a20b0afbd52 |
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| Source note | uspto-grants-2010_02 |
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