HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1441474Generated: November 2, 2026
Thionyl Chloride → 7-[chloro(1-methyl-1H-imidazol-5-yl)(4-methylphenyl)methyl]-5-(3-chlorophenyl)-tetrazolo[1,5-a]quinazoline. hydrochloride
https://huagongshe.com/reaction/1441474
Participants
| Role | Name | HCID | Charge |
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| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-(3-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)-alpha-(4-methylphenyl)-tetrazolo[1,5-a]quinazoline-7-methanol | HCID 68687709 | — |
| Product | 7-[chloro(1-methyl-1H-imidazol-5-yl)(4-methylphenyl)methyl]-5-(3-chlorophenyl)-tetrazolo[1,5-a]quinazoline. hydrochloride | HCID 131727375 | — |
Reaction Steps
A mixture of intermediate 25 (0.0083 mol) in thionyl chloride (80 ml) was stirred at 60° C. for 3 hours, then cooled and the solvent was evaporated. The residue was taken up in DCM. The solvent was evaporated, yielding 7-[chloro(1-methyl-1H-imidazol-5-yl)(4-methylphenyl)methyl]-5-(3-chlorophenyl)-tetrazolo[1,5-a]quinazoline. hydrochloride (1:1) (intermediate 26). This product was used directly in the next reaction step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07655654B2 |
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| Source dataset | uspto-grants-2010_02 |
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| ORD ID | ord-60cc833da79349a8a11c8c00504683bc |
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| Source note | uspto-grants-2010_02 |
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