反应详情

6-Methoxy-4-[(trimethylsilyl)ethynyl]-nicotinaldehyde (0.25 g, 1.1 mmol) and 7M ammonia in MeOH (5 mL) were stirred in a sealed vial at 80° C. overnight. The solution was concentrated, taken up in saturated sodium carbonate and extracted with ether. The organic phase was dried, filtered and concentrated to give 0.20 g of the title product.

1. concentrationThe solution was concentrated
2. extractionextracted with ether
3. customThe organic phase was dried
4. filtrationfiltered
5. concentrationconcentrated