1-Chloroethyl chloroformate → HCID 66734806, compound

Participants

Reaction Steps

A mixture of 2-tert-butyl-6-(2-cyclopropylpyrimidin-5-yl)-1,2,3,4-tetrahydro-2,7-naphthyridine (0.12 g, 0.39 mmol), 1-chloroethyl chloroformate (1.0 mL, 5.8 mmol) and toluene (10 mL) was refluxed for 4 h under protection from moisture (calcium chloride tube). After concentration to dryness, the dark residue was taken up in MeOH (10 mL) and refluxed for 3 h more. Charcoal (1 g) was added and refluxing continued for 20 minutes. Then the mixture was filtered through Celite and the clear filtrate was concentrated to give the title compound (0.12 g) as a solid.

Provenance & Evidence