HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boronic Acid → 2-Cyclopropylpyrimidine-4-boronic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boronic Acid | HCID 61668 | — |
| Reactant | 1,3,5,2,4,6-Trioxatriborinane | HCID 136134 | — |
| Reactant | 4-Bromo-2-cyclopropylpyrimidine | HCID 45787576 | — |
| Product | 2-Cyclopropylpyrimidine-4-boronic Acid | HCID 66734761 | 90% |
Reaction Steps
The title compound was prepared from 4-bromo-2-cyclopropylpyrimidine (WO 00/066566) in 90% yield (25 mmol scale) following the procedure by Li et al. (J. Org. Chem. 2002, 67, 5394-5397). LC-MS suggested that the product was composed of the boronic acid and the trimeric anhydride (sym-boroxine).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655664B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-29e1a31173c749d7ab55e28fa1292af5 |
| Source note | uspto-grants-2010_02 |