(4S)-(4-cyclopropyl-2,5-dioxoimidazolidin-4-yl)methanesulfonyl chloride → (5S)-5-Cyclopropyl-5-({[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydroisoquinolin-2(1H)-yl]sulfonyl}methyl)imidazolidine-2,4-dione

HRID 1441500Notes

Reaction equation

HRID 1441500 reaction equation
[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[CH2:16][NH:15][CH2:14][CH2:13]4)=[CH:6][N:5]=2)[CH2:3][CH2:2]1.[CH:20]1([C@@:23]2([CH2:30][S:31](Cl)(=[O:33])=[O:32])[C:27](=[O:28])[NH:26][C:25](=[O:29])[NH:24]2)[CH2:22][CH2:21]1>>[CH:20]1([C@:23]2([CH2:30][S:31]([N:15]3[CH2:14][CH2:13][C:12]4[C:17](=[CH:18][CH:19]=[C:10]([C:7]5[CH:8]=[N:9][C:4]([CH:1]6[CH2:3][CH2:2]6)=[N:5][CH:6]=5)[CH:11]=4)[CH2:16]3)(=[O:32])=[O:33])[NH:24][C:25](=[O:29])[NH:26][C:27]2=[O:28])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 59164390(4S)-(4-cyclopropyl-2,5-dioxoimidazolidin-4-yl)methanesulfonyl chlorideHCID 667348536-[2-(Cyclopropyl)pyrimidin-5-yl]-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 11662743(5S)-5-Cyclopropyl-5-({[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydroisoquinolin-2(1H)-yl]sulfonyl}methyl)imidazolidine-2,4-dione

Procedure

The title compound was prepared from 6-[2-(cyclopropyl)pyrimidin-5-yl]-1,2,3,4-tetrahydroisoquinoline and (4S)-(4-cyclopropyl-2,5-dioxoimidazolidin-4-yl)methanesulfonyl chloride using the general method described in Example 1.

Sources & evidence

ORD record
ord-80e29a102beb44cb9d57f50b69e57612
Source dataset
uspto-grants-2010_02
Patent number
US07655664B2

Reaction notes

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