Water → HCID 59164563, compound

Participants

Reaction Steps

The product of Step 2 (2.99 g, 7.14 mmol) and p-toluenesulfonic acid (1.62 g, 8.56 mmol) in acetic acid/water (40 ml/10 ml) were heated at 50° C. for 3 hours and then diluted (water) and extracted (diethyl ether). The organic phase was washed (saturated sodium hydrogen carbonate, brine), dried (magnesium sulfate) and evaporated in vacuo. The crude product was azeotroped with toluene, followed by ethyl acetate, followed by dichloromethane. The crude product then was chromatographed on silica, eluting with 30% ethyl acetate/isohexane to give the cyclohexanone (1.7 g, 64%).

Provenance & Evidence