Sulfuric Acid → HCID 11965617, compound

HRID 1441580Notes

Reaction equation

HRID 1441580 reaction equation
OS(O)(=O)=O.[CH3:6][O:7][C:8](=[O:28])[C:9]1[CH:14]=[C:13]([C:15]2[CH:19]=[CH:18][O:17][CH:16]=2)[C:12]([C:20]([F:23])([F:22])[F:21])=[CH:11][C:10]=1[NH:24]C(=O)C>CO>[CH3:6][O:7][C:8](=[O:28])[C:9]1[CH:14]=[C:13]([C:15]2[CH:19]=[CH:18][O:17][CH:16]=2)[C:12]([C:20]([F:22])([F:23])[F:21])=[CH:11][C:10]=1[NH2:24]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 59164437HCID 59164437, compound

Product 1

HCID 11965617HCID 11965617, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
90 °C

Procedure

Concentrated H2SO4 (1.4 mL) was added to a solution of 2-acetylamino-5-furan-3-yl-4-trifluoromethyl-benzoic acid methyl ester (156 mg, 0.47 mmol) in MeOH (15 mL). The mixture was stirred for 1 h (TLC control) at 90° C. The mixture was filtered over Celite and evaporated under reduced pressure. The yellow solid obtained was used in the next step without further purification (rt 5.95 min.).

Workup

  1. filtrationThe mixture was filtered over Celite
  2. customevaporated under reduced pressure
  3. customThe yellow solid obtained
  4. customwas used in the next step without further purification (rt 5.95 min.)

Sources & evidence

ORD record
ord-0c0042b0dec9407c89f4d823c7cc71d1
Source dataset
uspto-grants-2010_02
Patent number
US07655666B2

Reaction notes

Loading…