4-Chlorophenyl chloroformate → HCID 11965615, compound

HRID 1441582Notes

Reaction equation

HRID 1441582 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:3].[CH3:12][O:13][C:14](=[O:31])[C:15]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][O:23][CH2:22]2)[C:18]([C:26]([F:29])([F:28])[F:27])=[CH:17][C:16]=1[NH2:30]>O1CCOCC1>[CH3:12][O:13][C:14](=[O:31])[C:15]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][O:23][CH2:22]2)[C:18]([C:26]([F:28])([F:29])[F:27])=[CH:17][C:16]=1[NH:30][C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:3]

Participants

4

Reactant 2

HCID 1390594-Chlorophenyl chloroformateHCID 11965614HCID 11965614, compound

Product 1

HCID 11965615HCID 11965615, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

4-Chlorophenyl chloroformate (27.3 μL, 1.1 equiv) was added to a solution of 2-amino-5-(tetrahydro-furan-3-yl)-4-trifluoromethyl-benzoic acid methyl ester (51.3 mg, 0.18 mmol) in dioxane (500 μL). The mixture was then stirred for 2 h (TLC control) at 80° C. The mixture was evaporated to dryness. The product was used in the next step without further purification. (rt 6.87 min.)

Workup

  1. customThe mixture was evaporated to dryness
  2. customThe product was used in the next step without further purification
  3. custom(rt 6.87 min.)

Sources & evidence

ORD record
ord-ff5e0ddf8dc2462eb6cf041583b813cf
Source dataset
uspto-grants-2010_02
Patent number
US07655666B2

Reaction notes

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