Sodium Methoxide → HCID 68543391, compound

Participants

Reaction Steps

1-(methylcarbonyloxy-ethyl)-5(cyclooctyl-methyl)-spiro[indoline-3,4′-piperidin]-2-one (0.012 g, 0.028 mmol) was dissolved in methanol (1.5 mL). To the reaction mixture was then added at room temperature a 25% solution of sodium methoxide in methanol (50 μL) and the reaction mixture was stirred for 30 minutes. The solvent was evaporated in vacuo to yield an oil which was then partitioned with aqueous 0.1N HCl and dichloromethane. The organic layer was washed with brine, dried with Na2SO4, filtered and the solvent evaporated in vacuo to yield a crude oil. The crude oil was purified via flash chromatography (35% ethyl acetate/hexanes) to yield the title compound as an oil.

Provenance & Evidence