Trifluoroacetic acid → HCID 59164595, compound

Participants

Reaction Steps

1.1 g 4-{2-[[2-(4-Cyano-3-methyl-phenyl)-ethyl]-(6-trifluoromethyl-benzothiazol-2-yl)-amino]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester [prepared according to the method described in Example 1 and 5 from 4-(2-Amino-ethyl)-2-methyl-benzonitrile trifluoro acetate, N-boc-piperidinyl-4-acetaldehyde and 2-Chloro-6-trifluoromethyl-benzothiazole] were dissolved in 50 ml dichloromethane. 5 ml trifluoroacetic acid were added and the reaction mixture was stirred at room temperature for one hour. 150 ml ethyl acetate were added and the mixture was washed three times with saturated NaHCO3 solution. The organic layer was dried over MgSO4 and then the solvent was removed in vacuo. The residue was purified by RP-HPLC to obtain 325 mg 2-Methyl-4-{2-[(2-piperidin-4-yl-ethyl)-(6-trifluoromethyl-benzothiazol-2-yl)-amino]-ethyl}-benzonitrile.

Provenance & Evidence