反应详情

温度

25 °C

2-Fluoro-4-nitrobenzaldehyde (1.00 g, 5.92 mmol) and acetamidine hydrochloride (0.783 g, 8.28 mmol) were added to a suspension of activated 4 Å MS (1.2 g) in acetonitrile (60 mL). K2CO3 (1.14 g, 8.28 mmol) was then added and the reaction was heated to reflux for 4 h. The reaction was then cooled to 25° C. and filtered through celite rinsing with CH2Cl2. The crude product was purified by flash chromatography on silica eluting with 0-10% acetone in CH2Cl2 to give 0.386 g of compound 25A as a yellow solid.

1. temperaturethe reaction was heated
2. temperatureto reflux for 4 h
3. filtrationfiltered
4. washthrough celite rinsing with CH2Cl2
5. customThe crude product was purified by flash chromatography on silica eluting with 0-10% acetone in CH2Cl2