反应详情

温度

95 °C

A mixture consisting of 30 mL dioxane, 15 mL water and 11.25 mL of 2M aqueous sodium hydroxide solution is added to 4-(4-methyl-1-piperazinyl)-3-(trifluoromethyl)-benzonitrile and the reaction mixture is shaken for 16 hours at 95° C. After cooling, the mixture is evaporated. The resulting residue is treated with water, the pH adjusted to ˜5-6 with 1M hydrochloric acid and the solvent evaporated off under reduced pressure. The residue is treated with hot methanol, the insoluble salt filtered off and the filtrate evaporated yielding the crude title compound which is used for the next step without further purification.

1. temperatureAfter cooling
2. customthe mixture is evaporated
3. additionThe resulting residue is treated with water
4. customthe solvent evaporated off under reduced pressure
5. additionThe residue is treated with hot methanol
6. filtrationthe insoluble salt filtered off
7. customthe filtrate evaporated