2-Methylimidazole → 3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzonitrile

HRID 1441747Notes

Reaction equation

HRID 1441747 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[C:5]#[N:6].[CH3:14][C:15]1[NH:16][CH:17]=[CH:18][N:19]=1>>[CH3:14][C:15]1[N:16]([C:2]2[CH:3]=[C:4]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=2)[C:5]#[N:6])[CH:17]=[CH:18][N:19]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrile

Product 1

HCID 672146433-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzonitrile

Procedure

The title compound is prepared using an analogous method as described in Example 1.1, utilising 3-fluoro-5-(trifluoromethyl)-benzonitrile (Lancaster Synthesis GmbH) and 2-methyl-imidazole (Fluka, Buchs, Switzerland), with a reaction temperature of 145° C. for 24 hours.

Sources & evidence

ORD record
ord-fff3ec2cd28c4aa3b32ab11403650382
Source dataset
uspto-grants-2010_02
Patent number
US07655669B2

Reaction notes

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