HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-Acetamino-5-chloronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 1-Chloro-5-nitronaphthalene | HCID 13245743 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Acetamino-5-chloronaphthalene | HCID 21874844 | 95.1% |
Reaction Steps
The above synthesized 1-chloro-5-nitronaphthalene (540 mg, 2.6 mmol) was dissolved in 10 mL AcOH, followed by treatment with 415 mg (7.43 mmol) iron powder and subsequently acylated with Ac2O (0.26 mL, 2.73 mmol) according to the procedure described in Example 209A to give 543 mg (95%) of 1-acetamino-5-chloronaphthalene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655689B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-1287e727b5f446fcadfd5ebda4da3039 |
| Source note | uspto-grants-2010_02 |