関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | NBD-Cl | HCID 25043 | — |
| 触媒 | Iron | HCID 23925 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 7-Chloro-2,1,3-benzoxadiazol-4-amine | HCID 21875167 | 94% |
反応手順
A solution of 1.0 g (5.02 mmol) of 4-chloro-7-nitrobenzofurazan in 20 mL AcOH, 10 mL EtOAc and 2 mL H2O was heated at 50° C. and treated with iron powder (1.4 g, 251 mmol). The mixture was heated at 80° C. for 30 min and then allowed to cool to rt. The mixture was filtered through Celite eluting with EtOAc. The filtrate was washed with sat. aq. NaHCO3, dried over MgSO4, and concentrated under reduced pressure to give compound 258A (0.80 g, 94%) as a red solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07655689B2 |
|---|
| 出典データセット | uspto-grants-2010_02 |
|---|
| ORD ID | ord-bb4ee3dd23b64e60940d8c5312313b58 |
|---|
| 出典メモ | uspto-grants-2010_02 |
|---|
