Ethanol → HCID 11507563, compound

HRID 1441932Notes

Reaction equation

HRID 1441932 reaction equation
[CH2:1]([NH:8][C:9](=[O:11])[OH:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[OH-].[K+].[CH2:14](O)[CH3:15]>O>[NH:8]1[C:14]2[C:15](=[CH:4][C:5]([O:11][C:9](=[O:10])[NH:8][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:6][CH:7]=2)[CH2:3][CH2:2][CH2:1]1

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 14741613HCID 14741613, compound

Product 1

HCID 11507563HCID 11507563, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Ni—Al alloy (0.098 g.) was added portionwise during 1 min. to stirring mixture of heptyl-carbamic acid quinolia-6-yl ester (0.145 g.), 10% potassium hydroxide in water (3.54 ml) and ethanol (10 ml) at 0-4° C. The reaction mixture was continued to stir for additional 2.5 hours while the temperature of the reaction mixture was maintained at 50° C. The reaction mixture was filtered, Ni—Al alloy was discarded through filtration, and the filtrate was concentrated under vaccum. The residue so obtained was crystallized with methanol (or acetone) to give 2b; yield: 0.10 g. (67.7%).

Workup

  1. stirringto stir for additional 2.5 hours while the temperature of the reaction mixture
  2. filtrationThe reaction mixture was filtered
  3. filtrationNi—Al alloy was discarded through filtration
  4. concentrationthe filtrate was concentrated under vaccum
  5. customThe residue so obtained
  6. customwas crystallized with methanol (or acetone)

Sources & evidence

ORD record
ord-9b33100c93bc44009d4455478ffc3116
Source dataset
uspto-grants-2010_02
Patent number
US07655801B2

Reaction notes

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