Cyclopentanecarboxylic acid, 2-oxo-, methyl ester → HCID 68540960, compound

Participants

Reaction Steps

To a solution of methyl 2-oxocyclopentanecarboxylate (15.6 mg, 0.11 mmol) and (R,R)-trans-1-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(N,N-dimethylamino)cyclohexyl]thiourea (4.1 mg, 0.01 mmol) in toluene (1 mL) was added diethyl azodicarboxylate (45.5 μL, 0.10 mmol) at room temperature. After stirring for 0.5 hr, the reaction mixture was concentrated. The residue was purified by silica gel column (hexane/ethyl acetate=3/1) to give the title compound (41.4 mg, yield: 92%).

Provenance & Evidence