Hydrogen chloride-ethyl acetate → HCID 66783723, compound

HRID 1441955Notes

Reaction equation

HRID 1441955 reaction equation
[CH3:1][N:2]1[C:6]([CH3:8])([CH3:7])[CH2:5][S:4][C:3]1=[N:9][NH:10][C:11](=[O:30])[C:12](=[O:29])[CH:13]([NH:20][C:21]([CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1)=[O:22])[CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[ClH:31].C(OCC)(=O)C>>[ClH:31].[CH3:1][N:2]1[C:6]([CH3:8])([CH3:7])[CH2:5][S:4][C:3]1=[N:9][NH:10][C:11](=[O:30])[C:12](=[O:29])[CH:13]([NH:20][C:21]([CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1)=[O:22])[CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66783724HCID 66783724, compound

Product 1

HCID 66783723HCID 66783723, compound

Procedure

By the same procedure as described in step 7 of example 1 using the compound prepared in step 1, a free compound of N′-(3,4,4-trimethyl-1,3-thiazolidin-2-ylidene)-[3-cyclohexylcarbonylamino-3-(tetrahydropyran-4-yl)-2-o xopropanohydrazide] was given. To the free compound was added 4N hydrochloric acid-ethyl acetate solution and the mixture was stirred for 1 hour at room temperature and the mixture was concentrated. The residue was washed with ehyl acetate to give N′-(3,4,4-trimethyl-1,3-thiazolidin-2-ylidene)-[3-cyclohexylcarbonylamino-3-(tetrahydropyran-4-yl)-2-oxopropanohydrazide] hydrochloride (140 mg).

Workup

  1. concentrationthe mixture was concentrated
  2. washThe residue was washed with ehyl acetate

Sources & evidence

ORD record
ord-c935f0c1406b43caa185b750b18fb745
Source dataset
uspto-grants-2010_02
Patent number
US07655804B2

Reaction notes

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