1,4-Dioxane hydrochloride → HCID 86612275, compound

HRID 1441977Notes

Reaction equation

HRID 1441977 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[C:24]([CH2:29][C@H:30]([N:35]([C:37](=[O:61])[C@H:38]([NH:53]C(OC(C)(C)C)=O)[CH2:39][CH2:40][CH2:41][NH:42][C:43]([O:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)=[O:44])[CH3:36])[C:31]([O:33][CH3:34])=[O:32])[CH:23]=2)=[CH:18][C:17]=1[CH2:62][C@H:63]([NH:78][C:79]([O:81][CH2:82][C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)=[O:80])[C:64]([O:66][C:67]1[C:72]([F:73])=[C:71]([F:74])[C:70]([F:75])=[C:69]([F:76])[C:68]=1[F:77])=[O:65])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>O1CCOCC1>[ClH:1].[NH2:53][C@H:38]([CH2:39][CH2:40][CH2:41][NH:42][C:43]([O:45][CH2:46][C:47]1[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=1)=[O:44])[C:37]([N:35]([CH3:36])[C@@H:30]([CH2:29][C:24]1[CH:23]=[C:22]([C:19]2[CH:20]=[CH:21][C:16]([O:15][CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)=[C:17]([CH2:62][C@H:63]([NH:78][C:79]([O:81][CH2:82][C:83]3[CH:84]=[CH:85][CH:86]=[CH:87][CH:88]=3)=[O:80])[C:64](=[O:65])[O:66][C:67]3[C:68]([F:77])=[C:69]([F:76])[C:70]([F:75])=[C:71]([F:74])[C:72]=3[F:73])[CH:18]=2)[CH:27]=[CH:26][C:25]=1[F:28])[C:31]([O:33][CH3:34])=[O:32])=[O:61]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86612273HCID 86612273, compound

Product 1

HCID 86612275HCID 86612275, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

37 ml of a 4M hydrogen chloride-dioxane solution are added to a solution of 1.038 g (crude product, about 0.92 mmol) of pentafluorophenyl (2S)-3-(4-(benzyloxy)-3′-{(2S)-2-[{(2R)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]-pentanoyl}(methyl)amino]-3-methoxy-3-oxopropyl}-4′-fluorobiphenyl-3-yl)-2-{[(benzyloxy)carbonyl]amino}propanoate (Example 21O) in 19 ml of anhydrous dioxane at 0° C. After 1 h at 0° C., the reaction solution is concentrated in vacuo, coevaporated several times with dichloromethane and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-989d27e4d6e645de828a586b0eb7acad
Source dataset
uspto-grants-2010_02
Patent number
US07655643B2

Reaction notes

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