反应详情

The filtrate of (3S)-3-{[(benzyloxy)carbonyl]amino}-6-[(tert -butoxycarbonyl) amino]hexanoyl methyl carbonate (Example Z1) is added dropwise to a suspension of 0.49 g (13.14 mmol) of sodium borohydride in 0.6 ml of water at 0° C. The mixture slowly warms to RT and is stirred overnight. The reaction solution is concentrated, and the residue is mixed with ethyl acetate and water. The organic phase is dried over magnesium sulfate, concentrated and dried under high vacuum. The crude product is reacted without further purification.

1. customslowly warms to RT
2. concentrationThe reaction solution is concentrated
3. additionthe residue is mixed with ethyl acetate and water
4. dry with materialThe organic phase is dried over magnesium sulfate
5. concentrationconcentrated
6. customdried under high vacuum
7. customThe crude product is reacted without further purification