HCID 45142042, compound → 849815-17-4

HRID 1441985Notes

Reaction equation

HRID 1441985 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][C@H:12]([NH:15]C(=O)OCC1C=CC=CC=1)[CH2:13][OH:14])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[NH2:15][C@H:12]([CH2:13][OH:14])[CH2:11][CH2:10][CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 45142042HCID 45142042, compound

Product 1

HCID 57440196849815-17-4

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 169 mg (0.48 mmol) of benzyl [(1S)-4-[(tert -butoxycarbonyl)amino]-1-(hydroxymethyl)butyl]carbamate (Example Z4) in 50 ml of ethanol is hydrogenated after the addition of 17 mg of palladium on activated carbon (10%) under atmospheric pressure at RT for 4 h. The mixture is filtered through kieselguhr, and the residue is washed with ethanol. The filtrate is evaporated to dryness in vacuo. The product is reacted without further purification.

Workup

  1. filtrationThe mixture is filtered through kieselguhr
  2. washthe residue is washed with ethanol
  3. customThe filtrate is evaporated to dryness in vacuo
  4. customThe product is reacted without further purification

Sources & evidence

ORD record
ord-8ebe6044951a4a349b68b613d68e9c7f
Source dataset
uspto-grants-2010_02
Patent number
US07655643B2

Reaction notes

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