反应详情

4-Benzyloxy-6-methyl-2-(methylsulfonyl)pyrimidine (Compound II-4) (0.45 g, 0.00162 mol) was added thereto and the resulting solution was allowed to react for about 2 hours at room temperature. The reaction solution was poured into water and extracted with ethyl acetate to separate an organic phase. The obtained organic phase was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, then dried over anhydrous sodium sulfate and thereafter concentrated. The concentrate was purified on silica gel column to obtain the end product.

1. customto react for about 2 hours at room temperature
2. extractionextracted with ethyl acetate
3. customto separate an organic phase
4. washThe obtained organic phase was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. customThe concentrate was purified on silica gel column
8. customto obtain the end product