Water → HCID 19690797, compound

HRID 1442Notes

Reaction equation

HRID 1442 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH3:15])[N:12]=[C:11](S(C)(=O)=O)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH2:20]>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([CH3:15])[N:12]=[C:11]([O:20][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 196908044-Benzyloxy-6-methyl-2-(methylsulfonyl)pyrimidine

Product 1

HCID 19690797HCID 19690797, compound

Procedure

4-Benzyloxy-6-methyl-2-(methylsulfonyl)pyrimidine (Compound II-4) (0.45 g, 0.00162 mol) was added thereto and the resulting solution was allowed to react for about 2 hours at room temperature. The reaction solution was poured into water and extracted with ethyl acetate to separate an organic phase. The obtained organic phase was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride, then dried over anhydrous sodium sulfate and thereafter concentrated. The concentrate was purified on silica gel column to obtain the end product.

Workup

  1. customto react for about 2 hours at room temperature
  2. extractionextracted with ethyl acetate
  3. customto separate an organic phase
  4. washThe obtained organic phase was washed successively with aqueous saturated sodium hydrogen carbonate and aqueous saturated sodium chloride
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated
  7. customThe concentrate was purified on silica gel column
  8. customto obtain the end product

Sources & evidence

ORD record
ord-340aa7277cd54868a6996a4b34326397
Source dataset
uspto-grants-1998_03
Patent number
US05726128

Reaction notes

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