HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Difluoroaniline → 2-chloro-N4-(3,4-difluorophenyl)-5-fluoro-4-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Product | 2-chloro-N4-(3,4-difluorophenyl)-5-fluoro-4-pyrimidineamine | HCID 22061049 | — |
Reaction Steps
In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 3,4-difluoroaniline gave 2-chloro-N4-(3,4-difluorophenyl)-5-fluoro-4-pyrimidineamine. 1H NMR (CDCl3): δ 8.10 (d, 1H, J=2.1 Hz), 7.72 (m, 1H), 7.22 (m, 2H), 6.95 (bs, 1H); LCMS: purity: 93%; MS (m/e): 260 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07655797B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-7749a9c9d1704e35b08464c38b304a23 |
| Source note | uspto-grants-2010_02 |