Acetone → Tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

HRID 144220Notes

Reaction equation

HRID 144220 reaction equation
[BH4-:25].[CH2:1]([CH:2]=[CH2:3])[C:4]1([C:17](=[O:18])[O:19][CH2:20][CH3:21])[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1.[CH3:27][C:28](=[O:29])[CH3:30].[CH3:31][OH:32].[Cl:22][CH2:23][Cl:24].[Na+:26].[OH2:33]>>[C:4]12([CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1)[C:17](=[O:18])[O:19][CH2:20][CH2:21]2

Participants

8

Reactant 7

HCID 180AcetoneHCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 6344DichloromethaneHCID 28123BorohydrideHCID 162182701-tert-Butyl 4-ethyl 4-(prop-2-en-1-yl)piperidine-1,4-dicarboxylate

Product 1

HCID 10015228Tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

Sources & evidence

ORD record
ord-28ef34110d264b148bd1cef2522aac7a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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