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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1442376Generated: October 30, 2026

2-Amino-2-methyl-1,3-propanediol → 3-(beta-D-Galactopyranosyloxy)-4-[(4-{3-[2-hydroxy-1-hydroxy-methyl-1-(methyl)ethylcarbamoyl]propyl)phenyl)methyl]-5-isopropyl-1H-pyrazole

https://huagongshe.com/reaction/1442376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-2-methyl-1,3-propanediolHCID 1531—
ReactantGlycinamide hydrochlorideHCID 2723639—
ReactantHCID 68537679HCID 68537679—
Product3-(beta-D-Galactopyranosyloxy)-4-[(4-{3-[2-hydroxy-1-hydroxy-methyl-1-(methyl)ethylcarbamoyl]propyl)phenyl)methyl]-5-isopropyl-1H-pyrazoleHCID 86606847—

Reaction Steps

The title compound was prepared in a similar manner to that described in Example 1 using 3-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloxy)-4-({4-[(1E)-3-carboxyprop-1-enyl]-phenyl}methyl)-5-isopropyl-1H-pyrazole and 2-amino-2-methyl-1,3-propanediol instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-({4-[(1E)-3-carboxyprop-1-enyl]-phenyl}methyl)-5-isopropyl-1H-pyrazole and glycinamide hydrochloride, respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07655632B2
Source datasetuspto-grants-2010_02
ORD IDord-329717d36f95416dbc9d245bb38ae413
Source noteuspto-grants-2010_02