HRID1442521

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58339653

未命名化合物

结构：CCOC(=O)C[C@H]1CC[C@H](CN(CC)c2ccc(C(F)(F)F)cc2C=O)CC1

HCID178471781

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C[C@H]1CC[C@H](CN(CC)c2ccc(C(F)(F)F)cc2CNc2ncc(OCCSC)cn2)CC1

HCID178471776

未命名化合物

PROCEDURE

实验过程

By using ethyl trans-[4-({[2-(formyl)-4-(trifluoromethyl)phenyl](ethyl)amino}methyl)cyclohexyl]acetate instead of 2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)benzaldehyde, the reaction with 5-[2-(methylthio)ethoxy]pyrimidin-2-amine and treatments were performed in the same manner as those of Step 4 of Example 1 to obtain ethyl trans-{4-[({2-[({5-[2-(methylthio)ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetate as a pale yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58d256636b354d7b8a9727c7496045e8
来源数据集: uspto-grants-2010_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07659271B2
来源说明: uspto-grants-2010_02

反应 SMILES

[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=1[N:13]([CH2:16][C@H:17]1[CH2:22][CH2:21][C@H:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:19][CH2:18]1)[CH2:14][CH3:15])=O.[CH3:29][S:30][CH2:31][CH2:32][O:33][C:34]1[CH:35]=[N:36][C:37]([NH2:40])=[N:38][CH:39]=1>>[CH3:29][S:30][CH2:31][CH2:32][O:33][C:34]1[CH:39]=[N:38][C:37]([NH:40][CH2:1][C:3]2[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=2[N:13]([CH2:16][C@H:17]2[CH2:18][CH2:19][C@H:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:21][CH2:22]2)[CH2:14][CH3:15])=[N:36][CH:35]=1