HCID 58679114, compound → HCID 58679068, compound

Participants

Reaction Steps

To a solution of methyl 5-(2,4-bisbenzyloxyphenyl)-6-(cyclohex-2-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylate in a mixture of methanol (6 ml) and tetrahydrofuran (16 ml) was added 20% palladium hydroxide/carbon (400 mg, 0.74 mmol). After stirring for 13 hr under hydrogen atmosphere (3.4 atm) at room temperature, the reaction mixture was filtered through celite, and the filtrate was concentrated. The precipitated solid was collected by filtration. The solid was washed with diisopropyl ether (5 ml×3), and dried under reduced pressure to give methyl 5-(2,4-bisbenzyloxyphenyl)-6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylate (1.12 g, yield 82%).

Provenance & Evidence