Hydrochloric Acid → HCID 68712079, compound

Participants

Reaction Steps

Concentrated HCl (10 mL, 10M, 0.3 mol) was added to benzyl 4-(8-amino-1-(pyridin-3-ylethynyl)imidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate (650 mg, 0.0014 mol) and the mixture was left to stir at rt overnight prior to dilution with with water (30 mL) and washing with diethyl ether (3×20 mL). The aqueous layer was concentrated in vacuo, to afford 3-piperidin-4-yl-1-(pyridin-3-ylethynyl)imidazo[1,5-a]pyrazin-8-amine hydrochloride (610 mg, 99%).

Provenance & Evidence