HCID 68542093, compound → HCID 23085215, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 2-(benzoylamino)-3-(3-cyanophenyl)2-propenoate (300 mg, 0.979 mmol) and 5% palladium/barium sulfate (60 mg) in tetrahydrofuran (3 mL) was stirred at 50° C. for 7.5 hours under a hydrogen flow. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was dissolved in tetrahydrofuran (3 mL) and 5% palladium/barium sulfate (90 mg) was added to the solution. The mixture was stirred at 50° C. for 8 hours under a hydrogen flow. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give the title compound (273 mg, 90%).

Provenance & Evidence