Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | Benzoic acid, 3-cyano-, methyl ester | HCID 83554 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 58610097 | HCID 58610097 | 29.1% |
Reaction Steps
A mixture of methyl 3-cyanobenzoate (967 mg, 6.00 mmol), methyl thiosalicylate (1.51 g, 8.98 mmol), triethylamine (1.5 ml, 11 mmol) and xylene (6 mL) was stirred at 145° C. for 22 hours under a nitrogen flow. After the reaction mixture was allowed to cool, the crystals were taken by filtration and recrystallized from methanol to give the title compound (519 mg, 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07659267B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-4a1909155dee40e1a7fa87ec8a4a1ab9 |
|---|
| Source note | uspto-grants-2010_02 |
|---|
