Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | Methyl 4-cyano-2-(ethylamino)benzoate | HCID 23076867 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 58610105 | HCID 58610105 | 22% |
Reaction Steps
A mixture of methyl 4-cyano-2-(ethylamino)benzoate (1.23 g, 6.02 mmol), methyl thiosalicylate (1.52 g, 9.04 mmol), triethylamine (1.7 mL, 12 mmol) and xylene (6 mL) was stirred at 145° C. for 18 hours under a nitrogen flow. After the reaction mixture was allowed to cool, the crystals were taken by filtration and recrystallized from methanol to give the title compound (450 mg, 22%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07659267B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-2f976b757e5b42358e5f2f7ca86d0cf6 |
|---|
| Source note | uspto-grants-2010_02 |
|---|
