Water → 869-24-9

HRID 1442653Notes

Reaction equation

HRID 1442653 reaction equation
N[C:2]1[N:6]([C:7]2[C:12]([Cl:13])=CC(C(F)(F)F)=CC=2Cl)N=C(C#N)[C:3]=1S(C(F)(F)F)=O.P([O-])([O-])([O-])=O.[K+].[K+].[K+].[CH3:35][CH2:36]CCCCC.C(OCC)(=O)C.O>C(#N)C>[Cl-:13].[Cl:13][CH2:12][CH2:7][NH+:6]([CH2:2][CH3:3])[CH2:35][CH3:36]

Participants

6

Reactant 4

HCID 962WaterHCID 3352FipronilHCID 62657Potassium Phosphate, TribasicHCID 21899848Ethylacetate heptane

Product 1

HCID 49964257869-24-9

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(0.19 g, 1.1 mmol) was added to a mixture of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylsulfinylpyrazole (0.4 g, 0.92 mmol) and tripotassium phosphate (0.77 g, 3.7 mmol) in acetonitrile (6 ml), and the mixture heated under reflux for 6 hours. After extractive workup (heptane-ethyl acetate, water) and chromatography the title product was obtained (0.15 g); 1H-NMR: 0.87 (3H), 2.40 (2H), 2.53 (2H), 2.98 (2H), 7.80 (2H); 19F-NMR: −64.2; −74.5 ppm.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 6 hours

Sources & evidence

ORD record
ord-13353dfe32584976810b7150df1bee55
Source dataset
uspto-grants-2010_02
Patent number
US07659288B2

Reaction notes

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