p-Toluenesulfonic acid monohydrate → HCID 59166705, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-[2-(4-benzyloxy-3-methyl-phenyl)-2-ethyl-butyrylamino]-3-hydroxy-benzoic acid methyl ester (2.15 g, 4.66 mmol) in toluene (50 mL) is treated with TsOH—H2O (443 mg, 2.33 mmol). The reaction is heated to 160° C. for 60 m. The reaction mixture is cooled down, and toluene is removed under vacuum. The residue is purified by column chromatography (10% EtOAc/Hex) to give the title compound as an oil (1.50 g, 72%) MS (ES) m/e: 444.2 (M+1).

Provenance & Evidence