Potassium Carbonate → HCID 59166712, compound

Participants

Reaction Steps

2-[1-Ethyl-1-(4-hydroxy-3-methyl-phenyl)-propyl]-benzooxazole-5-carboxylic acid methyl ester (2.10 g, 5.94 mmol) and 1-bromopinacolone (1.59 g, 8.87 mmol) and K2CO3 (2.04 g, 14.8 mmol) are reacted analogous to Example 1, step G to give the title compound as a pale yellow oil (2.55 g, 95%). H-NMR (ppm, CDCl3) δ: 8.43 (1H, d, J=1.3 Hz), 8.01 (1H, dd, J=1.8, 8.8 Hz), 7.42 (1H, d, J=8.4 Hz), 7.01 (1H, d, J=2.2 Hz), 6.96 (1H, dd, J=2.2, 8.4 Hz), 6.51 (1H, d, J=8.8 Hz), 4.84 (2H, s), 3.95 (3H, s), 2.38 (2H, q, J=7.5 Hz), 2.32 (2H, q, J=7.5 Hz), 2.25 (3H, s), 1.25 (9H, s), 0.76 (6H, t, J=7.5 Hz).

Provenance & Evidence