Sodium borohydride → HCID 11711850, compound

Participants

Reaction Steps

2-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzooxazole-5-carboxylic acid (0.58 g, 1.33 mmol) in THF (30 mL) at RT is treated with NaBH4 (100 mg, 2.65 mmol). The resulting mixture is stirred for 1 h. The reaction is quenched with HCl (1.0 N, 5.0 mL) and extracted with EtOAc (3×50 mL). The organic layer is dried over Na2SO4 and concentrated to afford the title compound (0.58 g, 100%). MS (ES) m/e: 440.3 (M+1), 438.2 (M−1).

Provenance & Evidence