反应详情

温度

55 °C

A 12 L, Pyrex glass, four-neck, round bottom flask was equipped with an overhead stirrer, thermocouple temperature read out, reflux condenser, and heating mantle. The flask was purged with dry nitrogen and the following reaction was conducted under an atmosphere of dry nitrogen. The flask was charged with 1000 g of N-(5-chloro-salicyloyl)-8-aminooctanic acid and 3000 mL of absolute ethanol. This slurry was heated to 55° C. with stirring to obtain a slightly hazy solution. The reactor was then charged with 2276 g of 11.2 wt % sodium hydroxide dissolved in absolute ethanol as rapidly as possible. There was a slight exothermic reaction causing the temperature in the reactor to rise to about 64° C. and a precipitate began to form. The reflux condenser was removed and the reactor set for distillation. The reaction mixture was distilled over the next three hours to obtain about 2566 g of distillate. The pot slurry was allowed to cool slowly to room temperature. The product solids in the slurry were recovered by vacuum filtration through a sintered glass funnel to obtain 1390 g of ethanol wet cake. The wet cake was transferred to glass trays and placed in a vacuum oven. The cake was dried to constant weight at about 45° C. and full vacuum. The dry product had a weight of about 1094.7 g.

1. customA 12 L, Pyrex glass, four-neck, round bottom flask was equipped with an overhead stirrer
2. temperaturereflux condenser
3. temperatureheating mantle
4. customThe flask was purged with dry nitrogen
5. customthe following reaction
6. customto obtain a slightly hazy solution
7. customa slight exothermic reaction
8. customto rise to about 64° C.
9. customto form
10. customThe reflux condenser was removed
11. distillationthe reactor set for distillation
12. distillationThe reaction mixture was distilled over the next three hours
13. customto obtain about 2566 g of distillate
14. temperatureto cool slowly to room temperature
15. filtrationThe product solids in the slurry were recovered by vacuum filtration through a sintered glass funnel
16. customto obtain 1390 g of ethanol wet cake
17. customThe cake was dried to constant weight at about 45° C.