Trifluoroacetic acid → HCID 53880136, compound

Participants

Reaction Steps

To a solution of (2S,4S)-4-Benzylsulfanyl-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester (Preparation 2, 130 mg, 3.3 mmol) in dichloromethane (2.5 ml) was added trifluoroacetic acid (2.5 ml) and the mixture stirred at room temperature under a nitrogen atmosphere for 36 hours. The solvent was removed under reduced pressure and the residue purified by ion-exchange chromatography using Dowex™ 50WX8-200 resin eluting first with water and then with 10% aq ammonia to give the title compound (66 mg, 75%) as a white solid.

Provenance & Evidence