(2S,4S)-4-(3-chloro-phenoxymethyl)-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester → (2S,4S)-4-(3-chloro-phenoxymethyl)-pyrrolidine-2-carboxylic acid

Participants

Reaction Steps

(2S,4S)-4-(3-chloro-phenoxymethyl)-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester (Preparation 46, 67 mg, 0.16 mmol) was dissolved in a solution of anhydrous hydrogen chloride in dioxane (4M, 5 ml) and stirred for 18 hours at room temperature. The solvent was removed under reduced pressure and the residue triturated with ethyl acetate to give the title compound as a white solid hydrochloride salt (13 mg, 27%)

Provenance & Evidence