HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Isoquinolinol → 1,2-Bis(1,1-dimethylethyl) (2S,4S)-4-(7-isoquinolinyloxy)-1,2-pyrrolidinedicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Isoquinolinol | HCID 459767 | — |
| Reactant | Di-tert-butyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 7408710 | — |
| Product | 1,2-Bis(1,1-dimethylethyl) (2S,4S)-4-(7-isoquinolinyloxy)-1,2-pyrrolidinedicarboxylate | HCID 59166755 | — |
Reaction Steps
The title compound was synthesised from (2S,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester (CAS Reg. No. 170850-75-6) and isoquinolin-7-ol using the same method as preparation 11 and gave the title compound as an oil in 15% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07659305B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-0c275a3bfeb54aa38097f7e3875ce0dd |
| Source note | uspto-grants-2010_02 |