Methylglyoxal → HCID 11298738, compound

Participants

Reaction Conditions

Reaction Steps

A 40% strength solution of 61.53 g of pyruvaldehyde in water (341.8 mmol) in 20 ml of water is added by slow dropwise addition INto a solution of 50 g (341.8 mmol) of triethylenetetraamine in 800 ml of distilled water cooled to 2° C. On completion of addition, the reaction mixture is adjusted to ambient temperature and 81.36 g (683.6 mmol) of benzotriazole are added in a single portion. A solution of glyoxal (40% in water) (341.8 mmol) in 200 ml of methanol is then added by slow dropwise addition. After 2 h of stirring at ambient temperature, 25.85 g (683.6 mmol) of NaBH4 are added in small portions. After 2 h of stirring at ambient temperature, the methanol is evaporated and 50 g of KOH pellets are added to the residue. The solution is then extracted with three 1.5 l portions of chloroform. After drying over MgSO4 and evaporation of the solvents, (IIb) is isolated in the form of an orange oil (28.50 g; yield=40%).

Provenance & Evidence