Thionyl Chloride → 1-Methylpiperidine-4-carbonyl chloride

HRID 1443036Notes

Reaction equation

HRID 1443036 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([C:9]([OH:11])=O)[CH2:5][CH2:4]1.S(Cl)([Cl:14])=O>>[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([C:9]([Cl:14])=[O:11])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27600434-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)

Product 1

HCID 4365031-Methylpiperidine-4-carbonyl chloride

Procedure

1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and resulting mixture stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.

Workup

  1. customresulting mixture
  2. dissolutiondissolved completely
  3. stirringThe reaction mixture was stirred for another 20 minutes
  4. concentrationconcentrated
  5. customThe product was used for the next step without further purification

Sources & evidence

ORD record
ord-013249f72f984da2b1e346210532f727
Source dataset
uspto-grants-2010_02
Patent number
US07659395B2

Reaction notes

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