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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1443049Generated: October 29, 2026

HCID 54061615, compound → HCID 45099860, compound

https://huagongshe.com/reaction/1443049

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 54061615HCID 54061615—
ReactantHCID 178418361HCID 178418361—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
ProductHCID 45099860HCID 4509986094.1%

Reaction Steps

To a solution of (S)-1-benzyl-4-[(1-methylpyrrolidin-2-yl)methyl]piperazine 0.71 g (2.61 mmol) in 40 ml THF was added 10% Pd/C 0.4 g and exposed to 1 atm hydrogen overnight. The reaction mixture was filtered. The filtrate was concentrated to give 0.450 g of desired product in 94% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07659395B2
Source datasetuspto-grants-2010_02
ORD IDord-ef278b3d3b784b759852bdff8d2b96ed
Source noteuspto-grants-2010_02