HCID 59716948, compound → HCID 68626046, compound

HRID 1443056Notes

Reaction equation

HRID 1443056 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[CH3:21][N:18]1[CH2:19][CH2:20][C:15]([CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:16][CH2:17]1

Participants

3

Reactant 1

HCID 59716948HCID 59716948, compound

Product 1

HCID 68626046HCID 68626046, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-benzyl-4-((1-methyl-4-phenylpiperidin-4-yl)methyl)piperazine (1.5 g, 4 mmol) and 20% PdOH/C in methanol (50 ml) was shaked in the hydrogenation bar under H2 50-60 psi for 18 hours. The mixture was then filtered and the solvent removed in vacuo to afford desired product.

Workup

  1. customfor 18 hours
  2. filtrationThe mixture was then filtered
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-69db84f24acf44788d93a07c9ed743cf
Source dataset
uspto-grants-2010_02
Patent number
US07659395B2

Reaction notes

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