HCID 86601370, compound → HCID 59166817, compound

Participants

Reaction Steps

Additional debenzylation reaction: To a solution of (S)-2-(2-benzyloxy-phenoxymethyl)-morpholine-4-carboxylic acid, tert-butyl ester (obtained as above, General Procedure D) in ethanol was treated with 10% Pd/C. The room temperature sample was hydrogenated at balloon pressure for 2 h, filtered then concentrated. The sample was dissolved into EtOAc, washed with sat. KH2PO4 and brine solutions, dried (MgSO4), filtered and concentrated to give (S)-2-(2-hydroxy-phenoxymethyl)-morpholine-4-carboxylic acid, tert-butyl ester as a light yellow oil.

Provenance & Evidence