Toluene → Morpholine

Participants

Reaction Conditions

Reaction Steps

To a solution of morpholinone 2 (0.255 g, 0.825 mmol) in toluene (10 mL), Red-Al (65% solution in toluene (0.8 mL, 2.55 mmol), was added dropwise at 0° C. over 20 min. The reaction mixture was stirred at 0-5° C. for 2.5 h. Excess Red-Al was destroyed by dropwise addition of 2 M NaOH solution (2.7 mL). The layers were separated and the aqueous layer was diluted with water (20 mL) and extracted with toluene (2×15 mL). The combined organic extract was washed with brine and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure and the product was purified on a column of silica gel using 10% methyl alcohol in ethyl acetate to give morpholine compound 3 (2-[Phenyl-(2-vinyl-phenoxy)-methyl]-morpholine) as a viscous colorless oil (0.154 g, 63%). 1H NMR (CDCl3) δ: 7.46-7.18 (m, 7H), 7.01 (m, 1H), 6.84 (t, 1H), 6.68 (d, 1H), 5.78 (dd, 1H), 5.29 (dd, 1H), 5.12 (d, 1H), 3.98-3.86 (m, 2H), 3.64 (dt, 1H), 2.86-2.72 (m, 2H), 2.66-2.54 (m, 2H); MS (ES) 296.1 [C19H21NO2+H]+; HPLC purity (94.3%); Analysis: Calcd. C19H21NO2.0.5H2O: C, 74.91; H, 7.23; N, 4.60. Found: C, 75.41; H, 7.09; N, 4.95.

Provenance & Evidence