(Pyridin-4-yl)boronic acid → HCID 59166826, compound

HRID 1443067Notes

Reaction equation

HRID 1443067 reaction equation
Br[C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][CH:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:6]1[CH2:11][NH:10][C:9](=O)[CH2:8][O:7]1.[N:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[C:13]1([C@H:5]([O:4][C:3]2[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=2[C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)[C@H:6]2[O:7][CH2:8][CH2:9][NH:10][CH2:11]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 68539147HCID 68539147, compound

Product 1

HCID 59166826HCID 59166826, compound

Procedure

(S)-2-[(S)-Phenyl-(2-pyridin-3-yl-phenoxy)-methyl]-morpholine was synthesized from 6-[(2-Bromo-phenoxy)-phenyl-methyl]-morpholin-3-one and 4-pyridineboronic acid according to general procedures A and B and was isolated as a gummy oil. MS (APCI): 347 [M+H]+.

Workup

  1. customwas isolated as a gummy oil

Sources & evidence

ORD record
ord-9035496758d84d1d8a66d28159107828
Source dataset
uspto-grants-2010_02
Patent number
US07659394B2

Reaction notes

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