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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1443078Generated: November 1, 2026

Methanesulfonate → (R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholine

https://huagongshe.com/reaction/1443078

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonateHCID 85257—
Reactant6-HydroxybenzofuranHCID 128844—
Reactant2-(Hydroxy-phenyl-methyl)-morpholine-4-carboxylic acid tert-butyl esterHCID 60051021—
Product(R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholineHCID 68541124—

Reaction Steps

(R)-2-[(S)-(Benzofuran-6-yloxy)-phenyl-methyl]-morpholine was synthesized from 2-(Hydroxy-phenyl-methyl)-morpholine-4-carboxylic acid tert-butyl ester and 6-hydroxybenzofuran according General Procedure C employing the alternate etherification sequence (via the mesylate) and was isolated as an oil. MS (APCI): 310 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07659394B2
Source datasetuspto-grants-2010_02
ORD IDord-bd8daf2d111f45cf84c4b59e6ac87810
Source noteuspto-grants-2010_02