Sodium Bicarbonate → HCID 58893047, compound

Participants

Reaction Steps

Under an atmosphere of argon, tetrakis(triphenylphosphine)palladium(0) (20.4 mg, 0.018 mmol), 4-aminomethylphenylboronic acid (110.0 mg, 0.587 mmol), and a 1 M aqueous solution of sodium bicarbonate (1.75 mL, 1.75 mmol) were added sequentially to a solution containing 7-chloro-9-ethyl-1-thia-2,4a-diazacyclopenta[b]naphthalene-3,4-dione (33.0 mg, 0.118 mmol) and dimethylformamide (3.0 mL). The resulting orange mixture was irradiated in a microwave for 15 min (110° C.; 300 W) to give a red mixture. The solvent is evaporated under reduced pressure (˜10 mm Hg, 50° C.), and the remaining orange solid is washed with diethyl ether (3×15 mL).

Provenance & Evidence